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doi: 10.1016/j.intimp.2023.110141 [DOI] [PubMed] [Google Scholar] 97

Lei G, Zhang Y, Koppula P, Liu X, Zhang J, Lin SH, et al

Immunomodulation of tumor cells mediated by ferroptosis Immunogenic cell death (ICD) is a regulated form of cell death that elicits adaptive immunity by mediating the generation of neoantigens as well as the release of damage-associated molecular patterns (DAMPs) and cytokines [124]

A study 14 found that in APP/PS1 mutant mice, the decrease in ALDH2 activity could lead to a cascade of downstream events, including disruption of mitochondrial integrity, accumulation of mitochondrial DNA in the cytoplasm, downregulation of the cGAS-STING-TBK1 signaling pathway, and inhibition of autophagy and mitophagy, ultimately resulting in cardiac disorders

Chemotherapy treatment takes a lot out of you