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[DOI] [PubMed] [Google Scholar] 49.Richardson CJ, Blocka KL, Ross SG, et al
Phase I metabolic reactions introduce a hydrophilic group in the drug molecules where phase II metabolic reactions can take place
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This balance is primarily accomplished via the ribonucleotide reductase (RNR) complex in de novo synthesis (Fig 13)
Retrospective 76 COVID-19 patients, 46 treated with intravenous high-dose vitamin C, showing lower mortality and improved oxygen requirements with treatment
