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In an experimental model, transgenic mice expressing a kinase-deficient IGF-1R -subunit (thus displaying reduced signal transduction in both IGF-1R and hybrid receptors) developed diabetes early on life [162, 236]

Indian J Pediatr

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But IGF-1 also plays an important role once we reach adulthood: The hormone helps regulate our metabolism and helps us build and maintain lean muscle mass, among others
