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BCRP is densely expressed in the liver, kidney, blood-brain, intestine, and placental barriers (Doyle and Ross, 2003)

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FIGURE 5 Consistent with the protein level changes, quantitative real-time PCR (qPCR) analysis shows that PA significantly downregulates the mRNA expression levels of the crucial anti-ferroptosis genes GPX4, SLC7A11, and NRF2 in both NSCLC cell lines in a dose-dependent manner (Figures 5B,C)