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dry, patchy, or scaly skin Urticaria Acne Tissue swelling Hives Common gastrointestinal symptoms that may show up are: Chronic constipation Loose stools or diarrhea Flatulence and bloating Stomach cramps Leaky gut Nausea and/or vomiting SIBO Histamine intolerance and mast cell instability can also affect the nervous system and cardiovascular system, leading to symptoms including: Chills and shivers Sweating Low blood pressure High blood pressure Arrhythmia (irregular heart rate) Palpitations Sleep disorders or trouble sleeping Anxiety Dizziness Difficulty regulating body temperature Unexplained exhaustion Tremors Brain fog or trouble focusing People who have histamine intolerance can experience a diverse range of different symptoms that some may dismiss or misdiagnose

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The proportion of the dose metabolised by this pathway increases in overdose and, potentially, in the presence of other pathological/physiological states [13, 18,19,20]