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This combination significantly lowered the F/B ratio, increased butyrate levels, elevated anti-inflammatory cytokines (transforming growth factor-) and antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase), and decreased the expression of pro-inflammatory cytokines and hypoxia-inducible factors (Interferon-, IL-1, IL-6, TNF-, and HIF-1), thereby protecting gut barrier function