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As an illustration that the effects of organism-wide NRF2 activation differ from tissue-specific NRF2 activation, germline Keap1 -null mice die at an early age (36) (see above), whereas liver-specific Keap1 knockout results in healthy mice that are markedly resistant to the lethal toxicity of N -acetyl- p -aminophenol (91)

Skin purging is a reaction to an active ingredient that speeds up skin cell turnover rate

Equivalent amounts of protein (20 g) from each sample were subjected to electrophoresis on a SDS-polyacrylamide gel and were then transferred onto polyvinylidene difluoride membranes for subsequent blotting with specific antibodies

& Fairman, R