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Circulation 145 , 14601470 (2022)

IGF-1 can act over its putative receptor (IGF-1R) or it can also bind to the insulin receptor (IR), albeit with less affinity [98100]

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After cerebral ischemia/reperfusion in rats, rosmarinic acid was found to increase the phosphorylation of Akt1, decrease the phosphorylation of JK3, and decrease the expression of cleaved caspase-3 to protect hippocampal neurons in the brain (Zhang et al., 2017c)