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In some cases, the sequential use of different B12 status biomarkers or the calculation of a composite B12 status score (derived from a panel of B12 biomarkers and adjusted for folate status and age) can be used to detect deficient states that may otherwise be overlooked when using a single biomarker approach such as a B12 level (92)

Moreover, daratumumabs activity was validated in newly diagnosed MM patients [73] and those with intermediate-risk/ high-risk smoldering MM [74]

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