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GHK-Cu is explored for its ability to support tissue repair pathways through cellular signaling and growth factor modulation

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The glycosaminoglycan (GAG, a proteoglycan side chain) content decreases and catabolic matrix metalloproteinase (MMP) activity and denatured collagen content increases - the latter creating a more rigid IVD matrix reviewed in [2, 5, 6]

doi: 10.1016/0090-6980(81)90123-4