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Some areas of the body have a more easily accessible layer of tissue, where a needle injected under the skin will not hit muscle, bone, or blood vessels

In addition, most injectable migraine medications are not recommended during pregnancy, and CGRP antagonists should be stopped months before conceiving

Once into the brain, Vit B12 interacts with genes (LRRK2), proteins (synuclein and Lewy bodies), neurotransmitters (dopamine, Acetylcholine (Ach)) and metabolites that do impact on CNS hemostasis

Poor vitamin B 12 status in infancy is linked to poor growth and neurodevelopment

It is important to check and replace folate after starting B12 therapy, as coexisting deficiencies are common and correcting B12 alone can precipitate or worsen folate deficiency