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Previous studies also showed that some patients showing no evident cerebellar atrophy respond well to immunotherapies and that the clinical improvement correlates well with a fall in Ab titers [3, 6]

However, translational challenges persist, including the lack of pharmacokinetic standardization between oral and intravenous routes, tumor-type-specific response heterogeneity, and incomplete understanding of VCs immunomodulatory dynamics

However, both the chemical reduction of extracellular cystine by GSH released from astrocytes as well as transfer via extracellular vesicles should not be affected by inhibitors of the astrocytic GT or neuronal aminopeptidase N, which were shown to be involved in the supply of cysteine to neurons (Dringen, Pfeiffer, et al

Immune Function: Adequate glutathione levels support optimal immune cell function, which is particularly important for managing liver inflammation and preventing progression of liver disease