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Recent evidence suggests that 5-HT released from ECCs communicates with the gut microbiota, Turicibacter sanguinis , that possesses serotonin uptake mechanisms which are involved in its colonization and host physiology 125

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Later studies demonstrated that blocking the local release of norepinephrine inhibits cutaneous vasoconstriction during cold stress without affecting cutaneous vasodilation during heat stress (243) and that presynaptic blockade of cholinergic nerves results in an absence of active cutaneous vasodilation during heat stress (244)