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J Am Coll Surg (2020) 232(4):493502

The methylation status of the metabolism affects epigenetics in terms of DNA methylation and histone modification

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Alkaline pH, exposure to light and heat, and the presence of oxygen, water, or some metals (Cu, Fe) causes the oxidation of ascorbic acid through the dehydrogenation of the two hydroxyl groups at C 2 and C 3 , with the formation of DHA [73]