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Description
Rarely, patients with hepatic steatosis or cirrhosis present with Zieve syndrome (hyperlipidemia, hemolytic anemia, and jaundice)

Their nanoscale size allows them to cross the BBB and serve as natural carriers of bioactive molecules secreted by their parent cells or engineered drug delivery systems

BJS open 10(2), 2026

While the discovery of therapeutic strategies targeting TICs holds promise, our understanding of TIC biology remains limited due to the challenges in identifying and isolating them

10.1093/cvr/cvm047 Cardiovasc
