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This approach typically involves introducing an additive into the mobile phase to enhance the chromatographic retention of carnitines by forming ion pairs with them

In particular, creatine is an ergogenic aid (i.e., a temporal energy buffer) when supplementation is associated with high intensity exercise and the effect is more pronounced in untrained versus trained and in elderly versus young individuals [25], whereas similar changes in muscle performance have been found in males and females [14, 20]

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