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The first stage is the depolarization of neurons and glia and the release of excitatory amino acids, mainly glutamate

Nogueira et al., 2021) indicated by a decreased plasma arginine concentration in infected birds

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Many of the physiological problems that astronauts experience in space, such as motion sickness and otolith dysfunction as well as cardiovascular, bone, and muscle deterioration, are caused by the absence of normal terrestrial gravity (1 g) and the ensuing lack of mechanical stimulation of cells and tissues

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