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There are also challenges in the core capabilities of clinical trial sites, such as contract negotiation and institutional review time frames, study start-up, patient recruitment, and the completeness and quality of research data [9]

Researchers must reconstitute lyophilized peptides with bacteriostatic water, store at 28C, and use within 2830 days to maintain stability

When a DMC exists, the PI still has responsibilities A Data Monitoring Committee is not a substitute for site-level safety oversight
