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In particular, a detailed investigation was performed of the use of drug co-loaded (DOX and erlotinib) liposomes modified with transferrin (Tf) for receptor-mediated endocytosis and a cell-penetrating peptide, penetratin (Pen), against GBM, using tumor mice model [266]

Define a measurable outcome: weight, waist circumference, recovery time, or cognitive test
To minimize potential side effects, start with a lower dose and gradually increase it if necessary

As the data were not normally distributed, results from volunteer samples are expressed as medians with interquartile ranges (IQR), and nonparametric methods were applied

Caffeine induces Ca 2+ release by reducing the threshold for luminal Ca 2+ activation of the ryanodine receptor
