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This is a practical consideration, not a safety contraindication but its worth noting that the mechanisms work at cross purposes.

Instead, Jayawardena et al

During the surgical procedure, heating pads were used to maintain mouse body temperature and eye lubricant to keep moisture

A.DamjanovichS.2003Region Specific Vulnerability to Lipid Peroxidation in the Human Central Nervous SystemProc

Temozolomide induces senescence in both human and murine glioma cells and notably contributes to the accumulation of p16 INK4 positive senescent cells in mice [60, 69]
