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This is a practical consideration, not a safety contraindication but its worth noting that the mechanisms work at cross purposes.

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During the surgical procedure, heating pads were used to maintain mouse body temperature and eye lubricant to keep moisture

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Temozolomide induces senescence in both human and murine glioma cells and notably contributes to the accumulation of p16 INK4 positive senescent cells in mice [60, 69]

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