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The preclinical research suggests the receptor upregulation is time-dependent, so this is a real question
Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

In particular, the addition of vitamin C to the culture medium showed an increased production of L-DOPA and dopamine, mainly due to both an enhancement at metabolic level and involving the gene expression of the enzymes responsible for producing L-DOPA and dopamine

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