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The inhalation of smoke can trigger the production of significant amounts of inflammatory mediators, cytokines, and ROS in the lungs, leading to endothelial cell damage

[DOI] [PubMed] [Google Scholar] 41.Cerovecki T, Bojanic I, Brcic L, et al

Cells (7080% confluency) were incubated 24 h in advance with different working concentrations of DT-109

berberine isoquinoline alkaloid an antineoplastic, antidiabetic drug found in plants belonging to Berberidaceae family 12 , and Artemisinin, an antimalaria drug derived from Artemisia annua 13 , to mention a few