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It sustains adequate redox cell signaling since a physiologic level of oxidative stress is fundamental for controlling life processes via redox signaling, but excessive oxidation causes cell and tissue damage

Likewise, significant decreases in GSH/GSSG ratio in combination treatments compared to TGR inhibitors alone were also seen

Its accelerated approval was primarily based on a compelling reduction in plasma neurofilament light chain (NfL), a biomarker of neuronal damage, which decreased by approximately 60% in the tofersen group compared to 20% in the placebo group (44)

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