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The neuroprotective potential of the ketogenic diet is closely linked to its induced metabolic remodeling: by generating ketone bodies like -hydroxybutyrate, it activates astrocytic Nrf2 signaling to upregulate glutamate cysteine ligase, directly enhancing glutathione (GSH) synthesis and brain antioxidant capacity
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SOD2 and GPx1 are manganese-dependent superoxide dismutases that convert typical levels of superoxide generated by mitochondrial oxidative phosphorylation into hydrogen peroxide and water, respectively (Palma et al., 2020
