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In addition, the development of immunopeptidome analysis should provide successful targets and open the way to a new generation of senolytic treatments

Animal studies reveal that they can enter all tissues, including the brain

In Alzheimer's disease (AD), melatonin allows AD patients to enter REM sleep more quickly by modulating GABA receptors [87]

[DOI] [PubMed] [Google Scholar] [50].Haanp M, Attal N, Backonja M, Baron R, Bennett M, Bouhassira D, Cruccu G, Hansson P, Haythornthwaite JA, Iannetti GD, Jensen TS, Kauppila T, Nurmikko TJ, Rice ASC, Rowbotham M, Serra J, Sommer C, Smith BH, Treede RD, NeuPSIG guidelines on neuropathic pain assessment, Pain 152(1) (2011) 1427

Their properties are, however, strongly dependent on their composition and the preparation procedure