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For example, CCK1R-activated G q signaling is required for insulin secretion under low-glucose conditions, whereas G s signaling contributes more strongly to insulin secretion under high-glucose conditions 34

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Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism

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