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REACH, CLP, Cosmetics Regulation), if a substance is negative in the in vitro battery it is classified as non genotoxic, while a positive outcome in one or more of the in vitro tests requires confirmation by appropriate follow up in vivo testing

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Biomedicines 11 (2), 481
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VIP has shown to be a major neuroprotective factor against this inflammatory response by inhibiting microglia-derived proinflammatory factors