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Description
The Met-Glu-His-Phe sequence in Semax is extended by adding a Pro-Gly-Pro (PGP) sequence at its C-terminal end

Synergistic with GLP-1 agonists - the CagriSema combination (cagrilintide + semaglutide) shows 15.6% weight loss

States D

However, it has limited CNS bioavailability and lacks specificity, contributing to short-lived efficacy and side effects including confusion and hallucinations 60,61

[DOI] [PubMed] [Google Scholar] 157
