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Intriguingly, there appears to be data of a cumulative action after two or three presentations to the compound, with possibly elevated levels of both growth hormone and IGF-I above baseline on day 14 in many laboratory subjects
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doi: 10.1038/nm1577

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Conformational analysis of NMDA receptor GluN1, GluN2, and GluN3 ligand-binding domains reveals subtype-specific characteristics