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In many types of dementia, neuropathological lesions can be found in the ANS

When GPX4 is inhibited (for example, by RSL3) or when System Xc becomes dysfunctional, GSH levels are depleted (27, 28) (Figure 2)

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Um, uh, heavy duty toxins that are being released and your body's like, okay, I'm done for the day

Thus, the pyrimidine scaffold emerges as a promising motif combining strong target affinity with a slightly more selective ADME profile in its top analogues