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Collectively, these data confirm the involvement of lipid peroxidation with increased production of the by-product MDA, and high levels of ferrous iron which are consistent with the increased susceptibility to ferroptotic cell death in CF cells

Considering this pathway, the IMP levels in plasma after the treatment of dystrophic mice with DPSCs were comparable to those in the untreated controls and were not sufficient to restore purine levels in our study (Figure 3B)