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doi: 10.1098/rstb.2010.0149 8

Berberine inhibits the release of glutamate in nerve terminals from rat cerebral cortex

Glutathione acts on free radicals and enhances the effectiveness of other antioxidants in the body

Loss-of-function mutations in lysosomal proteins, as seen in Niemann-Pick disease type C1 and Gaucher disease, disrupt lipid and cholesterol metabolism and result in profound neurodegeneration
