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Study of the role of ascorbate in human brain function has been limited, but with the availability of suitable mouse models, ascorbate deficiency or excess can be studied in more detail, particularly with regard to effects of the vitamin on brain development, neurotransmitter function and responses to inflammatory or oxidant stresses, such as might exist in cerebral atherosclerosis or in several neurodegenerative diseases

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doi: 10.1016/j.fbio.2020.100619 107

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doi: 10.1530/REP-12-0404 32 AgarwalADurairajanayagamDHalabiJPengJVazquez-LevinM