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Trends Neurol

By providing exogenous pyridoxine that is readily converted to PLP, the injection corrects the coenzyme deficiency and reactivates these metabolic pathways

For instance, since one of the products of the reaction catalysed by gulonolactone oxidase is hydrogen peroxide, Halliwell suggested in 2001 that the loss of biosynthesis balanced the "cost" of production, since the advantage of producing one vitamin C molecule would be lost by the production of this reactive oxygen species (Halliwell 2001)

TB-500 has been examined in brain injury and neurodegeneration models with research documenting neuronal cell survival promotion through PI3K/Akt anti-apoptotic signalling, promotion of neurogenesis and oligodendrocyte progenitor migration following white matter injury, and anti-inflammatory effects in the injured CNS

63, 220224 10.1093/ajcn/63.2.220 [DOI] [PubMed] [Google Scholar] 34.van der Gaag M.S., Ubbink J.B., Sillanaukee P., Nikkari S