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RNA-Seq analysis of PCa cells treated with this p300-targeting peptide PROTAC revealed substantial induction of apoptosis and modulation of immune-related pathways (Zhang et al., 2024)

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In ALS, there is an abnormal cytoplasmic aggregation of misfolded proteins, mainly DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS) (Wijesekera and Leigh 2009)

This inhibitory effect is reversed with calcium supplementation
