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J.Fallier-BeckerP.Proikas-CezanneT.RiessO.et al (2016)
Neuron 108 , 11301145.e5 (2020)

NSAIDs also have harmful effects on the liver, kidneys, GI tract and cardiovascular system, while steroids can affect blood sugar levels and cause weight gain, exacerbating metabolic issues that contribute to knee OA

We assessed heterogeneity among the studies with the I 2 statistic, where a value above 50% indicated substantial/considerable heterogeneity [18]
