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[DOI] [PMC free article] [PubMed] [Google Scholar] 229.Anukunwithaya T., Tantisira M.H., Tantisira B., Khemawoot P

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Head-to-head comparisons between arginate and acetate forms in controlled human studies would quantify the bioavailability advantage in clinical terms

However, frequent dosing of senolytics may increase the risk of adverse effects, making it essential to find the right balance between efficacy and safety.36 Emerging clinical and preclinical evidence suggests that intermittent senolytic dosing may reduce the risk of cumulative toxicity, including thrombocytopenia observed with agents such as navitoclax, while preserving efficacy.36 Continuous dosing, while potentially providing sustained clearance, increases exposure-related risks