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The study also identified disease-specific hydroxymethylation regions (DhMRs) associated with positive epigenetic regulatory factors influencing gene expression, such as axonal guidance signaling, GABA receptor signaling, and Wnt/-catenin/Sox, affecting neuronal development and function in HD pathogenesis (213)

Cytoplasmic glutathione levels impact glutathione diffusion through nuclear pore complexes [55], playing a role in oxidative signaling during proliferation, epigenetic control of histone activity, and the cell cycle control, mainly in the S + G 2 /M phase [56,57]

& Hein, J
Organellar homeostasis and innate immune sensing
