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If H 2 O 2 remains in the mitochondrial matrix it reacts with the ferrous (Fe 2+ ) iron via the Fenton reaction yielding the hydroxyl free radical which is highly reactive toward DNA and polyunsaturated fatty acids (PUFA)

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And protein kinase A phosphorylates hormone-sensitive lipase, the enzyme that physically breaks triglycerides apart into free fatty acids and glycerol

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