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Structural work using cryo-electron microscopy has begun to map how cagrilintide engages these calcitonin- and amylin-receptor complexes, clarifying the binding determinants that distinguish selective from non-selective agonists

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The key difference lies in receptor selectivity

Contradictory or context-dependent effects Even though Nrf2 activation is generally cytoprotective in oxidative and electrophilic stress models, the pathway is highly context-dependent and may have some negative outcomes