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To investigate the mutational profile of the mutations resulting from each gene deficiency, regression with the full model was repeated on each of the six substitution types as well as on the 96 trinucleotide mutation classes, using the total burden of each mutation type as the response variable
It is estimated that the prevalence of PD in the general population is 0.3%, about 1% in people over 60 years old, and about 3% in people over 80 years old, with an incidence of 818 per 100,000 person-years (Tanner and Goldman, 1996

His treatment, an iridotomy, is still done today in patients with a type of glaucoma called angle closure

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