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Thus, heparinized human whole blood was first incubated with LPS for 16 h to induce the expression of COX-2 and mPGES-1 (in contrast to constitutively expressed COX-1 and cPGES)
The only clinical study that was designed to define a harmful threshold involved patients with cardiac arrest in which a PaO 2 threshold of 300 mmHg was identified, but this study was retrospective and other confounders could not be excluded 91
Front Pharmacol (2022) 13:825287
Zou and Kumar, 2018)
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