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Given the numerous CF animal models [162,163,164,165], preclinical studies examining this possibility are feasible

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On the contrary, most lncRNAs targeting c-Met compete for endogenous RNAs (ceRNAs), decoys, or sponges, and combine with specific miRNAs to prevent the inhibition of c-Met, including ceRNAs: lnc-XIST, lnc-MALAT1, lnc-GAPLINC, lnc-HOTAIR targeting miR-34 (Md Yusof et al., 2020), LINC00240 targeting miR-4465 (Cui et al., 2019), LNCRNA ZFAS1 targeting miR-193a-3p (Bu et al., 2020), lncRNA UCA1 targeting miR-1271-5p (Yang and Chen, 2019), etc

Although combinations of different anti-angiogenic agents might increase treatment benefit, the presence of many alternative pathways can still result in acquired resistance