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By doing so, activation of the collateral pathways, bypassing vascular key depending on the given injury, may occur as a particular consequent effect of the therapy [18,19,20,21,22,23,24,25,26,27,28,29,30]

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The effect of growth hormone on the insulin-like growth factor system during fasting

The above considerations suggest that two pharmacologically distinct mechanisms with opposite effects on the same signaling pathway are involved in a normally unresolvable physiological failure (complete obstruction (ligation) of vessels and ischemia due to a cause that could be not removed, inadequate rescue and unable to heal)