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First, the inner mitochondrial membrane (IMM) must be physically intact so that protons can only re-enter the matrix of the mitochondrion by a process coupled to ATP synthesis

Curr Opin Pharmacol 9, 753762 (2009)

Put the needle at a 90-degree angle into the muscle

AF declares that his institution has received funding from Amicus and Sanofi-Genzyme
Parenteral Vitamin B12 is the recommended treatment and will be required for the remainder of the patient's life
