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Concussion is characterized by a metabolic cascade where ions and metabolites are in a dynamic flux 5 , suggesting neurochemistry has the potential to be disturbed following concussion 5,6,7,8,9

Vesicular formulations may exhibit a slower drug release rate, which can reduce the concentration gradient across the skin and thereby limit transdermal diffusion, resulting in lower cumulative drug permeation into the receptor medium [58, 63]

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Research status Phase 3 complete for monotherapy and CagriSema