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However, ATP consumption is also lower ( Figure 4C ) due to the lower levels of Na + /K + -ATPase (40, 41), and therefore ATP supply is not necessarily a limiting factor

These transcription factors subsequently activate the expression of Stearoyl-CoA Desaturase 1 (SCD1), which catalyzes the synthesis of long-chain monounsaturated fatty acids, such as oleic acid, thereby reducing the membranes susceptibility to oxidation and sensitivity to ferroptosis [119, 120]

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To view a copy of this licence, visit About this article Cite this article Salah, R.S., Mahmoud, A.A., El-Shiekh, R.A