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This effect extended beyond simply mopping up free radicals-the pterostilbene treatment induced the up-regulation of other protective antioxidants, including glutathione, superoxide dismutase, and catalase

Szabo, 1998

Mutations in frataxin result in Friedrichs ataxia, a neurodegenerative disease featuring limb ataxia, muscle weakness, and cardiomyopathy [109]

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The differential metabolites and metabolic pathways identified in this paper should be further studied using targeted metabolomics, lipidomics, and proteomics, in order to elucidate mechanisms and screening therapeutic targets for developing early diagnostic strategies and treatments