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This action is associated with a reduction in HIF- expression and inhibition of the PI3K/Akt pathway
Rheumatoid arthritis association at 6q23
doi: 10.18632/aging.204579 67 ZhuYSuiBLiuXSunJ
From these results, authors concluded that attenuating the pro-inflammatory acute phase with IGF-I/IGFBP-3 may prevent multiple organ failure and improve clinical outcomes after thermal injury without any detectable adverse side effects
Therefore, it decreases antioxidant defense and enhances oxidative stress in cells
