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The concentration of MOTS-c influenced the expressions of these genes, and knockdown of TGF- or SMAD7 partially reversed the increase in collagen expression, indicating the involvement of the TGF-/SMAD pathway

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Chronic oral toxicology studies in Han Wistar rats (6 months) and cynomolgus monkeys (9 months) found no treatment-related unscheduled deaths, toxicologically significant clinical signs, or adverse changes in organ masses, electrocardiographic parameters, or histological profiles at the concentrations examined